|
| Scientific Publications |
| 41. Total Chemical Synthesis of all di-Ubiqutin Chains, K. S. Ajish Kumar, Liat Spasser, Lesly A. Erlich, Sudhir N. Bavikar, and Ashraf Brik* Angewandte Chemie, In press. | | | 40. Ziv Harpaz, Peter Siman, K. S. Ajish Kumar, and Ashraf Brik* : Protein Synthesis Assisted by Native Chemical Ligation at Leucine, ChemBioChem, 2010, 11, 1232-1235. PDF | | | 39. K. S. Ajish Kumar and Ashraf Brik*: Accessing Posttranslationally Modified Proteins through Thiol Positioning, Journal of Peptide Science, In press | | | 38. Mahmood Haj-Yahya, K. S. Ajish Kumar, Lesly A Erlich, and Ashraf Brik*: Protecting Group Variations of δ-Mercaptolysine Useful in Chemical Ubiquitylation, Biopolymers, 2010, 94, 504-510. PDF | | | 37. Ashraf Brik*: New Strategies for Glycopeptides, Neoglycopeptides and Glycoproteins Synthesis, In Comprehensive Natural Products II Chemistry and Biology; Mander, L., Lui, H.-W., Eds.; Elsevier: Oxford, 2010; volume 6, pp.55–89. | | | 36. Lesly A. Erlich, K. S. Ajish Kumar, Mahmood Haj-Yahya, Philip E. Dawson and Ashraf Brik*: N-Methylcysteine-Mediated Total Chemical Synthesis of Ubiquitin Thioester, Organic & Biomolecular Chemistry, 2010, 8, 2392-2396 PDF | | | 35. K. S Ajish Kumar, Mahmood Haj-Yahya, Diana Olschewski, Hilal A. Lashuel and Ashraf Brik*: Highly Efficient and Chemoselective Peptide Ubiquitylation, Angewandte Chemie, 2009, 48, 8090-8094. (See highlight about this paper in C&EN, November 16, 2009, Volume 87. PDF | | | 34. K. S Ajish Kumar, Ziv Harpaz, Mahmood Haj-Yahya and Ashraf Brik*: Side-Chain Assisted Ligation in Protein Synthesis, Bioorganic & Medicinal Chemistry Letters, 2009, 19, 3870–3874.
PDF | | | 33. Natalia Nepomniaschiy, Valerie Grimminger, Aviv Cohen, Saviana DiGiovanni, Hilal Lashuel* and Ashraf Brik*: Switch Peptide via Staudinger Reaction, Organic Letters, 2008, 11, 5243-5246.
PDF | | | 32. Ashraf Brik*: Metathesis in Peptides and Peptidomimetics, Advanced Synthesis and Catalysis, 2008, 350, 1661-1675 PDF | | | 31. Marina-Yamit Lutsky, Natalia Nepomniaschiy and Ashraf Brik*: Peptide Ligation via Side-Chain Auxiliary, Chemical Communications, 2008, 10, 1229-1231 PDF | | | 30. Michael J. Giffin, Holly Heaslet, Ashraf Brik, Ying-Chuan Lin, Gabrielle Cauvi1, Chi-Huey Wong, Duncan E. McRee, John H. Elder, C. David Stout and Bruce E. Torbett1 "AB2, an Azide-Alkyne Click Compound, is a Potent Protease Inhibitor of Multidrug-Resistant HIV-1" Journal of Medicinal Chemistry, 2008, 51, 6263-6267. PDF | | | 29. Clay S. Bennett, Richard J. Payne, Simon Ficht, Stephen M. Dean, Ashraf Brik, and Chi-Huey Wong: Sugar-Assisted Glycopeptide Ligation with Complex Oligosaccharides, Journal of The American Chemical Society, 2008, 130, 11945-11952. PDF | | | 28. Chi-Huey Wong, Ashraf Brik, Yu-Ying Yang, Simon Ficht, Richard Payne “Method of preparing glycopeptides” PCT Int. Appl. (2007), CODEN: PIXXD2 WO 2007111952 A2 20071004 AN 2007:1116927 | | | 27. Richard J. Payne, Simon Ficht, Sishi Tang, Ashraf Brik, Yu-Ying Yang, David A. Case and Chi-Huey Wong, “Extended Sugar-Assisted Glycopeptide Ligations: Development, Scope and Applications” Journal of The American Chemical Society, 2007, 129, 13527-13536. PDF | | | 26. Yu-Ying, Yang, Simon Ficht, Ashraf Brik* and Chi-Huey Wong* “Sugar-Assisted Ligation in Glycoprotein Synthesis” Journal of the American Chemical Society, 2007, 129, 7690-7701. PDF | | | 25. Ashraf Brik* and Chi-Huey Wong* “Sugar-Assisted Ligation for the Synthesis of Glycopeptides” Chemistry-A European Journal, 2007, 13, 5670-5675. PDF | | | 24. Simon Ficht, Richard J. Payne, Ashraf Brik and Chi-Huey Wong “Second Generation Sugar-Assisted ligation: An effective New Method for the Synthesis of Cysteine Containing Glycopeptides” Angewandte Chemie International Edition, 2007, 46, 5975-5979 PDF | | | 23. Ashraf Brik,* Simon Ficht, Yu-Ying Yang, and Chi-Huey Wong* “Sugar Assisted ligation for the Synthesis of N-linked Glycopeptide with Broad Sequence Tolerance at the Ligation Junction” Journal of the American Chemical Society, 2006, 128, 15026-15033. See highlight about this paper in News & Views, Nature, 2007, 445, 31-33 PDF | | | 22. Ashraf Brik, Simon Ficht, and Chi-Huey Wong “Strategies for the Preparation of Homogenous Glycoproteins” Current Opinion in Chemical Biology, 2006, 10, 1-7 PDF | | | 21. Ying-Chuan Lin, Ashraf Brik, Aymeric de Parseval, Karen Tam, Bruce Torbett, Chi-Huey Wong, and John H. Elder “Altered Gag-Pol Polyprotein Cleavage Specificity of FIV/HIV Mutant Proteases as Demonstrated in Cell-Based Expression System” Journal of Virology, 2006, 80, 7832-7843 PDF | | | 20. Ashraf Brik, Yu-Ying Yang, Simon Ficht and Chi-Huey Wong, “Sugar Assisted Glycopeptide Ligation” Journal of The American Chemical Society, 2006, 128, 5626-5627 PDF | | | 19. Ashraf Brik, Chung-Yi Wu and Chi-Huey Wong “Microtiter Plate Based Chemistry and In Situ Screening: A Useful Approach for Rapid Inhibitors Discovery" Organic & Biomolecular Chemistry, 2006, 4, 1446-1457 PDF | | | 18. Fu-Sen Liang, Ashraf Brik, Ying-Chuan Lin, John H. Elder, and Chi-Huey Wong. “Epoxide Opening in Water for Rapid Inhibitor Discovery in Microtiter Plate and In situ screening” Bioorganic & Medicinal Chemistry, 2006, 14, 1058-1062 PDF | | | 17. Chung-Yi Wu, Ashraf Brik, Sheng-Kai Wang, Yu-Hsien Chen, and Chi-Huey Wong “Tetrabutylammonium Fluoride-Mediated Rapid Alkylation Reaction in Microtiter Plates for Discovery of Enzyme Inhibitors In situ” ChemBiochem, 2005, 6, 2176-2180 PDF | | | 16. Ashraf Brik, Jerry Alexandratos, Ying-Chuan Lin, John H. Elder, Arthur J. Olson, David S. Goodsell, Alexander Wlodawer and Chi-Huey Wong “1,2,3 Triazole as a Peptide Bond Surrogate in the Rapid Synthesis of HIV Protease Inhibitors“ ChemBiochem, 2005, 6, 1167-1169 (highlighted on the cover page) PDF | | | 15. Ashraf Brik, Chung-Yi Wu, Michael D. Best and Chi-Huey Wong “Tetrabutylammonium Fluride-Assisted Rapid N9-Alkylation on Purine Ring: Application to Combinatorial reaction in Microtiter plates for the Discovery of Potent Sulfotransferase Inhibitors In situ“ Bioorganic & Medicinal Chemistry, 2005, 13, 4622-4626 PDF | | | 14. Ashraf Brik and Ehud Keinan, “Catalytic Antibodies in Natural Product Synthesis” Catalytic Antibodies, Ehud Keinan, ed. (WILEY-VCH), 2005, 132-152 PDF | | | 13. Chung-Yi Wu, Jia-Tsrong Jan, Shiou-Hwa Ma, Chih-Jung Kuo, Hsueh-Fen Juan, Yih-Shyun E Cheng, Hsuan Cheng Huang, Douglass Wu, Ashraf Brik, Fu-Sen Liang, Rai-Shung Liu, Jim-Min Fang, Shui-Tein Chen Po-Huang Liang, and Chi-Huey Wong “Small Molecules Targeting Severe Acute Respiratory Syndrome (SARS) Human Coronavirus" Proceedings of the National Academy of Science, USA, 2004, 101(27), 10012-10017 PDF | | | 12. Norman Metanis, Ashraf Brik, Ehud Keinan, and Philip E. Dawson, “Electrostatic interaction dominate the contribution of Arg39 in 44 Oxalocrotonate Tautomerase” Journal of the American Chemical Society”, 2004, 126 (40), 12726-12727 PDF | | | 11. Ting-Jen Chen, Ashraf Brik, Chi-Huey Wong and Chen-Chen Kan. “A model System for High-Throughput Screening of Novel Human Immunodeficiency Virus (HIV) Protease Inhibitors in Escherichia Coli” Antimicrobial Agents and Chemotherapy, 2004, 48(7), 2437-2447 PDF | | | 10. Michael D. Best, Ashraf Brik, Lac V-Lee, Ali Chapman, Wei-Chieh Cheng and Chi-Huey Wong. “Rapid Discovery of Potent Sulfotransferase Inhibitors by Diversity-Oriented Reaction in Microplates Followed by in Situ Screening" ChemBioChem, 2004, 5, 811-819 PDF | | | 9. Ashraf Brik, John Muldoon, Ying-Chuan Lin, John H. Elder, David S. Goodsell, Arthur J. Olson, Valery V. Fokin, K. Barry Sharpless and Chi-Huey Wong. “A Rapid Diversity-Oriented Synthesis and In Situ Screening of HIV Protease Inhibitors.” ChemBioChem, 2003, 4, 1246-1248 PDF | | | 8. Chi Ching Mak, Ashraf Brik, Danica L. Lerner, John H. Elder, Garrett M. Morris, Arthur J. Olson, and Chi-Huey Wong, “Design and Synthesis of Broad-Based Mono- and Bi-cyclic Inhibitors of FIV and HIV Proteases" Bioorganic & Medicinal Chemistry, 2003, 11, 2025-2040 PDF | | | 7. Ashraf Brik and Chi-Huey Wong, “ HIV Protease: Mechanism and Drug Discovery.” Organic & Biomolecular Chemistry, 2003, 1, 5-14 (highlighted on the cover page),(Top 10 most downloaded OBC articles in 2006-2007 and 2009) PDF | | | 6. Ashraf Brik, Ying-Chuan Lin, John Elder and Chi-Huey Wong, “A Quick Diversity-Oriented Amide-Forming Reaction to Optimize p-subsite Residues of HIV Protease Inhibitors” Chemistry & Biology, 2002, 9, 891-896 PDF | | | 5. Ashraf Brik, Lawrence J. D’Souza, Ehud Keinan, Flavio Grynszpan and Philip E. Dawson, “Mutants of 4-Oxalocrotonate Tautomerase Catalyze the Decarboxylation of Oxaloacetate Through an Imine Mechanism” ChemBioChem, 2002, 3, 845-851, (highlighted on the cover page) PDF | | | 4. Ashraf Brik, Philip E. Dawson and Ehud Keinan, “The Product of the Natural Reaction Catalyzed by 4-oxalocrotonate Tautomerase Becomes an Affinity Label of its Mutant.” Bioorganic & Medicinal Chemistry, 2002,10, 3891-3897 PDF | | | 3. Ashraf Brik, Ehud Keinan, and Philip E. Dawson, “Protein Synthesis by Solid-Phase Chemical Ligation Using a Safety Catch Linker" Journal of Organic Chemistry, 2000, 65, 3829-3835 PDF | | | 2. Nizar Haddad, Michael Grishko, and Ashraf Brik “Studies Towards Total Synthesis of Borrelidin, Stereoselective Synthesis of the Polysubstituted Macrolidic Part" Tetrahedron Letters, 1997, 38, 6075-6078 PDF | | | 1. Nizar Haddad, Ashraf Brik, and Michael Grishko “Studies Towards Total Synthesis of Borrelidin, Regioselective Methylation of Bis-epoxides and Structure Determination" Tetrahedron Letters 1997, 38, 6079-6082 PDF | |
|
|
